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目的:探讨过敏性紫癜合并消化道出血的相关危险因素。方法:回顾性分析2013年9月至2016年6月在武汉协和医院儿科住院治疗的80例过敏性紫癜初诊患儿的临床资料,根据是否合并消化道出血分为消化道出血组11例,非消化道出血组69例,比较两组患儿的年龄、地区、性别、发病季节、紫癜分布特征、是否合并紫癜性肾炎、hsCRP、ESR、血常规、生化等。结果:与非消化道出血组相比,消化道出血组患儿的发病季节、血清超敏C反应蛋白(hsCRP)、血清钙离子(Ca)水平差异均有统计学意义(P<0.05),两组紫癜性肾炎发病率比较差异无统计学意义,但消化道出血组合并紫癜性肾炎的比例(45.5%)明显高于非消化道出血组(21.7%)。结论:夏冬季节、高水平血清CRP、低水平血清Ca~(2+)是过敏性紫癜患儿合并消化道出血的危险因素。
Objective: To explore the related risk factors of allergic purpura with gastrointestinal bleeding. Methods: The clinical data of 80 newly diagnosed children with Henoch-Schonlein Purpura who were hospitalized in Peking Union Medical College Hospital from September 2013 to June 2016 were retrospectively analyzed. According to whether there were 11 cases of gastrointestinal bleeding combined with gastrointestinal bleeding, Gastrointestinal bleeding group, 69 cases were compared between the two groups of children age, sex, sex, season of onset, purpura distribution, whether combined with purpuric nephritis, hsCRP, ESR, blood, biochemical and so on. Results: Compared with non-gastrointestinal bleeding group, the onset season, serum hsCRP and Ca levels in patients with gastrointestinal bleeding were significantly different (P <0.05) The incidence of purpura nephritis was no significant difference between the two groups, but the proportion of gastrointestinal bleeding combined with purpura nephritis (45.5%) was significantly higher than that of non-gastrointestinal bleeding (21.7%). Conclusion: In summer and winter, high level of serum CRP and low level of serum Ca ~ (2+) are the risk factors of gastrointestinal hemorrhage in children with Henoch-Schonlein purpura.