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目的观察辛伐他汀治疗轻、中度老年痴呆并高脂血症的临床疗效。方法选取2013年7月—2015年7月安康市人民医院收治的轻、中度老年痴呆并高脂血症患者86例,采用随机数字表法分为对照组和观察组,每组43例。对照组患者给予常规治疗,观察组患者在常规治疗基础上给予辛伐他汀治疗。比较两组患者治疗前后血脂指标及简易精神状态评价量表(MMSE)、临床痴呆评定量表(CDR)、日常生活自理量表(ADL)评分。结果两组患者治疗前血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异均无统计学意义(P>0.05);观察组患者治疗后血清TC、TG、LDL-C水平均低于对照组,血清HDL-C水平高于对照组(P<0.05)。两组患者治疗前MMSE、CDR及ADL评分比较,差异均无统计学意义(P>0.05);观察组患者治疗后MMSE评分高于对照组,CDR、ADL评分低于对照组(P<0.05)。两组患者治疗期间均未出现严重不良反应。结论辛伐他汀治疗轻、中度老年痴呆并高脂血症的临床疗效较好,且安全性较高。
Objective To observe the clinical efficacy of simvastatin in the treatment of mild to moderate senile dementia with hyperlipidemia. Methods Totally 86 patients with mild to moderate senile dementia and hyperlipemia who were admitted to Ankang People’s Hospital from July 2013 to July 2015 were randomly divided into control group and observation group with 43 cases in each group. Patients in the control group were given routine treatment, and patients in the observation group were given simvastatin on the basis of routine treatment. Serum lipids, MMSE, CDR and ADL scores before and after treatment were compared between the two groups. Results There was no significant difference in the levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) between the two groups before treatment (P> 0.05). The levels of serum TC, TG and LDL-C in the observation group were lower than those in the control group, and the serum HDL-C levels were higher than those in the control group (P <0.05). The scores of MMSE, CDR and ADL in two groups before treatment did not reach statistical significance (P> 0.05). MMSE score of the observation group was higher than that of the control group, and the score of CDR and ADL was lower than that of the control group (P <0.05) . Two groups of patients during the treatment did not appear serious adverse reactions. Conclusion Simvastatin is safe and effective in the treatment of mild to moderate senile dementia with hyperlipidemia.