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目的:探讨干扰素-γ(IFN-γ)和白细胞介素4(IL-4)在慢性阻塞性肺病(COPD)患者不同时期血清中的表达及临床意义。方法:分别于20例患者疾病急性加重期及缓解期测定反映Th1淋巴细胞功能的IFN-γ及反映Th2淋巴细胞功能的IL-4血清水平,比较急性加重期及缓解期上述炎症因子水平差异。结果:急性加重期血清IL-4水平与缓解期组比较有显著性差异(P<0.05)。结论:TH2细胞参与了COPD的气道炎症反应,血清IL-4是COPD急性加重期主要炎性因子。
Objective: To investigate the expression and clinical significance of interferon-γ (IFN-γ) and interleukin-4 (IL-4) in serum of patients with chronic obstructive pulmonary disease (COPD) at different stages. Methods: The levels of IFN-γ, which reflect the function of Th1 lymphocytes and the level of IL-4, which reflect the function of Th2 lymphocytes, were measured in 20 patients with acute exacerbation and remission. The levels of inflammatory cytokines in acute exacerbation and remission were compared. Results: Serum levels of IL-4 in acute exacerbation were significantly different from those in remission stage (P <0.05). Conclusion: TH2 cells are involved in airway inflammation in COPD. Serum IL-4 is the major inflammatory factor in acute exacerbation of COPD.