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Bladder cancer,which originating from urothelium,is one of the most common malignant tumors in the urinary system.The incidence rate is the eleventh in all malignant tumors worldwide,9.0/100,000 for men,and 2.2/100,000 for women.The incidence rate is the seventh for men and after tenth for women on malignant tumors;the mortality rate is 3.2/10 million for men and 0.9/10 million for women,and the mortality for men ranks the 9th in male malignant tumors.Regional,racial and gender differences are associated with the pathogenesis of bladder cancer,which are observed in all age groups.The highest incidence is between 50 and 70 years old,which increases with age.Between 2010-2014,the median diagnosis age was 73 years old,and the median age at death was 79 years old based on statistics data from US surveillance,Epidemiology,and End Results(SEER) database.