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孕妇在妊娠期有可能并发各种疾病须应用药物。自60年代妊娠期服反应停致海豹肢畸形事件发生后,药物的致畸作用备受重视。近年来,关于药物对胎儿、新生儿的影响,特别是在致畸方面进行了大量研究。统计结果表明,2％的新生儿某些器官的畸形与孕妇长期滥用药物有一定关系。药物的致畸作用与药物的种类、用药时期的孕周胎龄、药物的剂量及用药时间长短、药物的理化特性及孕妇吸收能力等因素密切相关。 一、妊娠期药物动力学
Pregnant women during pregnancy may be complicated by various diseases need to apply drugs. Since the 60s pregnancy reaction to stop the seal caused limb deformity event, the teratogenic effect of the drug has received great attention. In recent years, a large number of studies have been conducted on the effects of drugs on the fetus and newborn, especially in the field of teratogenicity. Statistics show that 2% of neonatal malformations in certain organs and pregnant women have a long-term drug abuse have a certain relationship. Teratogenic effects of drugs and the type of drug, gestational gestational gestational age, drug dosage and duration of medication, physical and chemical properties of drugs and absorption of pregnant women and other factors are closely related. First, the pharmacokinetics during pregnancy