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目的 :探讨中西医结合治疗慢性再生障碍性贫血 (CAA)作用机理。方法 :应用51 Cr标记技术和冷冻蚀刻电镜技术对 3 0例CAA患者经中西医结合治疗前后的红细胞(RBC)寿命进行了测定 ,对其膜蛋白形态和分布进行了观察 ,并与健康人 (3 0名 )作对照。结果 :CAA患者RBC寿命缩短 ,与健康对照组比较 ,有显著性差异 (P <0 0 1 ) ,治疗后RBC寿命延长并接近健康人 ;治疗前RBC质膜内片劈裂面和外片劈裂面均见蛋白微粒形态异常、数量减少和分布不均 ,治疗后膜蛋白微粒好转 ,并接近健康人。结论 :RBC寿命与膜蛋白的形态、数量、质量及分布密切相关。中西医结合治疗CAA的疗效明显优于单纯西药疗效 ,且有稳定膜蛋白、延长RBC寿命的作用。
Objective: To explore the mechanism of traditional Chinese and western medicine in treating chronic aplastic anemia (CAA). Methods: The life span of erythrocytes (RBCs) in 30 CAA patients before and after treatment with Chinese and Western medicine was determined by 51 Cr labeling and freeze-etching electron microscopy. Morphology and distribution of RBCs were observed and compared with healthy people ( 30) as a control. Results: The life span of RBC in CAA patients was shortened, which was significantly different from that in healthy controls (P <0.01). The life span of RBCs in patients with CAA was longer than that in healthy controls. Before treatment, Slit surface protein particles were abnormal morphology, the number of reduced and uneven distribution of membrane protein particles improved after treatment, and close to healthy people. Conclusion: The life span of RBC is closely related to the morphology, quantity, quality and distribution of membrane proteins. The combination of traditional Chinese and Western medicine treatment of CAA was significantly better than the efficacy of Western medicine alone, and a stable membrane protein, to extend the life of RBC role.