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本文分析了324例原发性肝癌(PHC)先证者的家族肿瘤史类型、分布及其与PHC 的关系.结果表明:①PHC 患者的家族肿瘤史主要为肝癌(88.27%),肝癌家族中发生2例或2例以上肝癌(不含先证者)的高发家族占38.81%.②有肝癌家族史的PHC 先证者发病高峰年龄(30～39岁)与有其它癌家族史的先证者(40～49岁)相比较提前一个年龄组(P<0.01).③不同家族肿瘤史组的PHC 先证者中,均为合并HBV 感染者多于未感染者,且有肝癌家族史的先证者HBV 感染率显著高于有其它癌家族史者(P<0.05).提示合并HBV 感染的肝癌高发家族成员是发生PHC 的高危人群,需密切注意.
This paper analyzed the family history of tumors in 324 cases of primary liver cancer (PHC) probands and their relationship with PHC. The results showed that: 1PHC patients had a history of family history of hepatocellular carcinoma (88.27%), which occurred in the liver cancer family. High-family families with 2 or more cases of hepatocellular carcinoma (without probands) accounted for 38.81%. 2 PHC proband with peak family history of histories (peak age 30–39 years) and probands with family history of other cancers (40 to 49 years old) compared to one age group in advance (P<0.01).3 Among the PHC probands of different family tumor histories, all had more HBV-infected patients than uninfected ones and had a family history of liver cancer. The HBV infection rate of the witnesses was significantly higher than those with other cancer family histories (P<0.05). This suggests that the high-family members of the hepatocellular carcinoma with HBV infection are high-risk groups with PHC.