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甲苯咪唑治疗人体的包虫病已逾5年。但对患者的血清或囊液中药物的利用力报道极少。作者对9例不宜手术的包虫病患者进行了试验观察。方法:口服甲苯咪唑40～200mg/kg/天,每8小时1次,1天3次分服。在治疗12～48周期间,于服药后1～3小时取血,用放射免疫法测定血清中甲苯咪唑药量的浓度,每周1次,连续4周,其后每2周测定1次。同时,询问药物副作用并检查血红蛋白、白细胞、血小板、天门冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶、胆红素、血清蛋白、尿、肌酐和电解质。结果9例包虫病患者均能耐受药物,2例患者转氨酶暂时上升,4～6周恢复正常,其它无异常变化。用甲苯咪唑40～60mg/kg/天治疗的7例患者,给药1～3小时后血中药物浓度经24次观察,均
Mebendazole treatment of human echinococcosis has more than 5 years. But the patient’s serum or cyst fluid drug utilization rarely reported. The author of nine cases of echinococcosis surgery should not be tested. Methods: oral mebendazole 40 ~ 200mg / kg / day, once every 8 hours, 3 times a day sub-service. During 12 to 48 weeks of treatment, blood was taken 1-3 hours after taking the drug, and the concentration of mebendazole in the serum was determined by radioimmunoassay once a week for 4 weeks and then once every 2 weeks. In the meantime, ask for side effects and check for hemoglobin, white blood cells, platelets, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, bilirubin, serum protein, urine, creatinine, and electrolytes. Results Nine patients with echinococcosis were able to tolerate the drug, 2 patients with transient increase in transaminases, 4 to 6 weeks returned to normal, the other no abnormal changes. 7 patients treated with mebendazole 40 ~ 60mg / kg / day, after 1 to 3 hours of administration of blood drug concentration after 24 observations, both