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目的观察新生儿颅内感染并发癫痫的发病率,研究新生儿颅内感染与癫痫发病之间的关系,以便指导临床预防性治疗。方法收集2010年6月-2013年7月在医院就诊的84例癫痫患儿进行回顾性分析,依据是否并发新生儿颅内感染分为感染组和非感染组,其中感染组41例,非感染组43例,非感染组排除持续性存在的病因所致癫痫的患儿,采用Cox模型分析探究影响新生儿癫痫发病的独立危险因素。结果治疗前感染组患儿的癫痫发作平均频率及每次发作的平均持续时间与非感染组患儿相比差异无统计学意义;经过积极的抗感染及控制癫痫治疗后,感染组患儿每天癫痫发作频率(14.38±5.23)d,持续时间(4.57±1.87)min,均明显低于未感染组的(17.05±6.53)d和(5.35±1.27)min,差异有统计学意义(P<0.05);经Cox模型分析得出:新生儿的颅内感染为癫痫发作的独立危险因素。结论新生儿的颅内感染为癫痫发作的独立危险因素,应引起注意。
Objective To observe the incidence of intracranial infection in neonates with epilepsy and to study the relationship between neonatal intracranial infection and epilepsy in order to guide clinical preventive treatment. Methods A total of 84 cases of epilepsy in our hospital from June 2010 to July 2013 were retrospectively analyzed. According to whether intracranial infection complicated with neonatal infection was divided into infected group and non-infected group, 41 cases were infected with non-infected Group, 43 cases of non-infected group excluding persistent etiology-induced epilepsy children with Cox model analysis to explore the impact of epilepsy neonatal independent risk factors. Results The average frequency of seizures and the average duration of each attack in children with infection before treatment were not statistically different from those in non-infected children. After positive anti-infection and control of epilepsy, The frequency of seizures was 14.38 ± 5.23 d and the duration was 4.57 ± 1.87 min, which was significantly lower than that of non-infected patients (17.05 ± 6.53 d and 5.35 ± 1.27 min, respectively) (P <0.05 ); Cox model analysis showed that: neonatal intracranial infection is an independent risk factor for seizures. Conclusion Neonatal intracranial infection is an independent risk factor for seizures and should be noted.