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作者采用双抗体夹心酶联免疫吸附法（ＥＬＩＳＡ）对２０例同种异体尸肾移植患者进行了８９例次可溶性白介素２受体（ＳＩＬ－２Ｒ）检查。结果表明：移植前明显高于正常对照组，Ｐ＜０．００１。移植后随着肾功能的恢复而接近正常，但仍轻度高于正常对照组，Ｐ＜０．０１。发生急性排斥反应时较稳定期明显升高，Ｐ＜０．００１，且其上升时间早于血肌酐上升２～７天。而发生环孢素Ａ肾中毒或急性肾小管坏死时，血清ＳＩＬ－２Ｒ水平则变化不明显，Ｐ＜０．０５。因此，ＳＩＬ－２Ｒ的测定可作为移植肾排斥反应诊断和鉴别诊断的重要非创伤性指标。
In this study, 89 patients with soluble interleukin-2 receptor (SIL-2R) were examined in 20 patients with allogeneic cadaveric renal allografts by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). The results showed that: before transplantation was significantly higher than the normal control group, P <0.001. With the recovery of renal function after transplantation and close to normal, but still slightly higher than the normal control group, P <0.01. Acute rejection reaction was more stable than the stable period, P <0.001, and its rise earlier than serum creatinine increased 2 to 7 days. The occurrence of cyclosporin A nephrotoxicity or acute tubular necrosis, serum SIL-2R levels did not change significantly, P <0.05. Therefore, the determination of SIL-2R can be used as an important non-invasive index for the diagnosis and differential diagnosis of renal allograft rejection.