【摘 要】
：
What is the rationale for immunotherapies in Parkinsonian syn-dromes (PS)? PS are neurodegenerative diseases which are clinically characterized by a hypokinetic
【机 构】
：
Department of Neurology, St. Josef-Hospital, Ruhr-UniversityBochum, Bochum, Germany“,”Neurodegenerat
论文部分内容阅读
What is the rationale for immunotherapies in Parkinsonian syn-dromes (PS)? PS are neurodegenerative diseases which are clinically characterized by a hypokinetic phenotype in combination with additional motor and non-motor symptoms. One major patholog-ical hallmark of all PS consists of a non-physiological detrimental accumulation of protein aggregates which appear intracellularly in neurons and glial cells but also in the extracellular space (Wong and Krainc, 2017). Depending on the pathogenic protein, PS can be divided into synucleinopathies, characterized by aggregation of the protein alpha-Synuclein (aSyn), and tauopathies, characterized by aggregation of the protein Tau (Levin et al., 2016; Poewe et al., 2017). Clinical syndromes of synucleinopathies include Parkinson’s disease (PD), multiple system atrophy (MSA) and dementia with Lewy bod-ies, and tauopathies include progressive supranuclear palsy (PSP) and corticobasal degeneration.
其他文献
The spatial arrangement of the cell is important and considered as underlying mechanism for mathematical modeling of cell to cell interaction. The ability of ce
Proteins might misfold during translation and folding or even once they are in their native states, due to stochastic fluctuations, destabilizing mu-tations or
Diabetes mellitus, together with its complications, has been increasing in prevalence worldwide. Its compli-cations include cardiovascular disease (e.g., myocar
A recent demographic shift towards increased age at time of spi-nal cord injury (SCI), as well as decreased functional recovery following SCI in older populatio
The sigma receptor (Sig-R) was first reported by Martin et al. (1976) and was initially classified into the opioid receptor family. However, Sig-R was subsequen
会诊讨论会rn何筱仙教授:患者病史5个月,右手肌无力,肌肉逐渐萎缩.1个月前跑步时自觉双足力弱,有“肌肉跳动感”,无肢体麻木疼痛.右手分指并指力量差,对指力、握力较对侧差.
The rat high-impact free weight drop model mimics the diffuse axonal injury caused by severe traumatic brain injury in humans, while severe controlled cortical
All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such
Combinations of biomaterials and cells can effectively target delivery of cells or other therapeutic factors to the brain to rebuild damaged nerve pathways afte
Neurodegenerative diseases with an iron accumulation compo-nent: A wide variety of neurological diseases are characterized by the accumulation of iron in differ