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目的:探讨食管癌合并脉管瘤栓患者的临床病理特点、与P53、Ki67、表达和5年生存率的关系。方法:回顾性分析84例食管癌合并脉管瘤栓患者的临床病理资料、P53、Ki67表达和5年生存率。结果:食管癌合并脉管瘤栓患者的淋巴结转移数目越多脉管瘤栓发生率越高(P<0.01);瘤细胞分化程度低/未分化癌较高/中分化的脉管瘤栓有显著意义(P<0.01);食管癌合并脉管瘤栓与免疫组化P53、Ki67阳性与阴性比较有差异(P<0.05)。食管癌患者5年生存率在脉管瘤栓阳性与阴性表达患者之间比较有显著差异(P<0.05)。结论:食管癌合并脉管瘤栓的发生与食管癌患者的年龄、性别无关;与临床病理的淋巴结转移数目及P53、Ki67的阳性表达呈正相关关系,与细胞分化程度表达呈负相关关系,合并脉管瘤栓患者预后差。把脉管瘤栓加入现行的TNM分期中结合P53、Ki67联合检测可能更具有临床指导意义。
Objective: To investigate the clinicopathological characteristics of esophageal carcinoma complicated with vascular tumor thrombus, and the relationship between P53, Ki67, expression and 5-year survival rate. Methods: The clinical and pathological data, P53, Ki67 expression and 5-year survival rate of 84 patients with esophageal cancer complicated with vascular tumor were retrospectively analyzed. Results: The higher the incidence of lymph node metastasis was (P <0.01), the lower the degree of differentiation of tumor cells / the higher / moderate differentiation of tumor vessels in esophageal carcinoma complicated with vascular tumor thrombus (P <0.01). The positive and negative expressions of P53 and Ki67 in esophageal cancer complicated with vascular tumor thrombus and immunohistochemistry were significantly different (P <0.05). The 5-year survival rate of patients with esophageal cancer was significantly different between patients with positive and negative control (P <0.05). Conclusions: The incidence of esophageal cancer complicated with vaso-tumor thrombus is not related to the age and sex of patients with esophageal cancer. There is a positive correlation between the number of clinical pathological lymph node metastasis and the positive expression of P53 and Ki67, and negatively correlated with the degree of cell differentiation Malignant thrombus in patients with poor prognosis. The combination of P53 and Ki67 in the current TNM staging may be more clinically instructive.