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患者男,38岁,因急性白血病人院治疗.疾病在完全缓解期(CR期),出现腹泻伴低热、血培养结果对氟哌酸敏感、故给予静注氟哌酸250ml,10分钟后感全身皮肤搔痒伴心慌、寒战,颜面及躯干皮肤发红伴斑丘疹、BPll/7kPa.考虑为变态反应、立即给予非那根、氟美松肌往及吸氧等,20分钟后痒感消失,丘疹渐融合成片状,压之退色,请皮肤科会诊为氟哌酸过敏.口服扑尔敏、Vit C.局部涂炉甘石洗剂,皮肤颜色逐渐正常.讨论:氟哌酸是一种全合成毗酮类抗生药.抗菌谱广.目前使用范围较广泛,静注氟哌酸出现副作用者少见,主要表现恶心、呕吐等消化道反应,偶有皮疹、瘙痒.本例静注10分钟后出现荨麻疹并心慌、寒战、血压下降等变态反应,经抗过敏治疗有效.氟哌酸是一种较好的新型药物,在临床应用时要注意患者的个体差异,重视变态反应,尤其是白血病病人和血小板下降者易引起严重合并感染而有致命的危险.
Male, 38 years old, hospitalized for acute leukemia.Disease (CR), diarrhea associated with fever, blood culture results were sensitive to norfloxacin, it is given intravenous norfloxacin 250ml, 10 minutes after the flu Systemic skin itching with palpitation, chills, facial and trunk skin redness with rash, BPll / 7kPa. Considering the allergy, immediately give finasteride, flumethasone and oxygen and so on, 20 minutes after the itching disappears, Papules gradually fused into a sheet, the pressure of the fade, dermatology consultation for norfloxacin allergy oral chlorpheniramine, Vit C. topical calamine lotion, skin color gradually normal.Conclusion: Norfloxacin is a All synthetic ketones antibiotic antibacterial spectrum wide currently use a wide range of intravenous norfloxacin side effects are rare, mainly nausea, vomiting and other gastrointestinal reactions, occasional rash, pruritus. The intravenous injection of 10 minutes After urticaria and palpitation, chills, blood pressure and other allergic reactions, anti-allergic treatment effective. Norfloxacin is a good new drug in the clinical application of individual patients should pay attention to differences, attention to allergies, especially Patients with leukemia and thrombocytopenia are likely to cause strict Severe combined infection and fatal danger.