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Some evidence suggests that multiwalled carbon nanotubes can promote neuronal differentiation and growth. The present study investigated the effect of functional multiwalled carbon nanotubes (MWCNTs) on functional recovery of injured sciatic nerves in mice. The results revealed that MWCNTs accelerated the recovery of functional index scores of injured sciatic nerves in mice. Moreover, the medullary sheath was significantly thicker in the injured sciatic nerve following MWCNTs administration. These effects were dose-dependent.