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目的:探讨川芎嗪联合缬沙坦治疗糖尿病肾病肾衰竭的临床疗效。方法:选择我院2011年1月至2013年1月收治的糖尿病肾病肾衰竭患者96例,并将其随机分为实验组和对照组,每组48例。两组患者均根据病情给予对症支持治疗,并严格控制血糖。在常规治疗基础上,实验组患者给予川芎嗪注射液240 mg,静脉滴注,1次/d,同时给予缬沙坦80 mg,口服,1次/d,21天为1个疗程;对照组患者给予缬沙坦80 mg,口服,1次/d,21天为1个疗程。1个疗程后观察两组患者的临床疗效、血液学指标、尿检指标等实验室检查。结果:治疗21天后,实验组的临床有效率达83.3%,显著高于对照组(60.4%),差异具有统计学意义(P<0.05);两组空腹血糖、尿蛋白、尿素氮、血肌酐水平均较治疗前显著改善,且实验组以上指标及胆固醇水平的改善程度明显优于对照组,差异有统计学意义(P<0.05)。治疗过程中,两组均无严重不良反应发生。结论:川芎嗪联合缬沙坦可以更有效地改善糖尿病肾病肾衰竭患者的临床疗效,有一定的临床应用价值。
Objective: To investigate the clinical efficacy of ligustrazine combined with valsartan in the treatment of diabetic nephropathy and renal failure. Methods: Ninety-six patients with diabetic nephropathy and renal failure admitted to our hospital from January 2011 to January 2013 were randomly divided into experimental group and control group, 48 cases in each group. Two groups of patients were given symptomatic supportive treatment according to the condition, and strictly control blood sugar. On the basis of conventional treatment, the experimental group was given Ligustrazine injection 240 mg, intravenous infusion, once a day, at the same time valsartan 80 mg, orally, once / d, 21 days for a course of treatment; control group Patients given valsartan 80 mg, orally, 1 / d, 21 days for a course of treatment. After a course of treatment, two groups of patients were observed in clinical efficacy, hematology, urine tests and other laboratory tests. Results: After 21 days of treatment, the clinical effective rate in the experimental group was 83.3%, which was significantly higher than that in the control group (60.4%), the difference was statistically significant (P <0.05). The fasting blood glucose, urine protein, urea nitrogen, (P <0.05). The levels of above indexes and cholesterol in experimental group were significantly better than those in control group (P <0.05). During treatment, no serious adverse reactions occurred in both groups. Conclusion: Ligustrazine combined with valsartan can more effectively improve the clinical efficacy of diabetic nephropathy in patients with renal failure, and has certain clinical value.