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目的:探讨可利新在急性缺血性肾衰(IARF)中的作用。方法:通过阻断SD大鼠肾动脉血流制作IARF模型,并将大鼠分为3组:对照组,治疗1组,治疗2组。分别给予0.09%生理盐水、可利新0.06mg/kg和0,03mg/kg静脉注射,第1次给药后24小时,观察肾皮质血流、肾功能和肾组织学改变。结果:与对照组相比,可利新组可明显增加肾缺血再灌注后肾皮质血流量(P<0.05),增加肾小球滤过率(P<0.05)并减轻肾组织损伤。两治疗组间无显著性差异。结论:可利新可能通过改变肾皮质血流的分布而增加肾小球滤过率,从而改善肾功能。
Objective: To explore the role of propranolol in acute ischemic renal failure (IARF). Methods: IARF model was made by blocking the renal artery blood flow of SD rats. The rats were divided into 3 groups: control group, treatment 1 group and treatment 2 groups. The rats were given 0.09% normal saline, 0.06mg / kg and 0.03mg / kg intravenously respectively. The changes of renal cortex blood flow, renal function and renal histology were observed 24 hours after the first administration. Results: Compared with the control group, Kelixin group significantly increased renal cortical blood flow (P <0.05), increased glomerular filtration rate (P <0.05) and decreased renal tissue injury. No significant difference between the two treatment groups. CONCLUSION: Prednisone may improve glomerular filtration rate by changing the distribution of renal cortical blood flow, thus improving renal function.