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多发性硬化被认为是Th1细胞介导的自身免疫病。近年来,一种以分泌IL-17为特征的Th17细胞被发现与自身免疫反应有关。越来越多的证据表明,Th17细胞参与自身免疫性炎症的病理过程,在实验性自身免疫性脑脊髓炎和多发性硬化的发生发展过程中发挥着重要作用。其介导多发性硬化的具体机制仍不清楚,可能与破坏血脑屏障、诱导单核细胞扩增并分化为髓样树突状细胞以及促进炎性细胞因子网络的形成等有关。本文综述了关于Th17细胞的发现、分化以及在多发性硬化发病机制中的作用。
Multiple sclerosis is thought to be Th1 cell-mediated autoimmune disease. In recent years, a type of Th17 cell characterized by secretion of IL-17 has been found to be involved in the autoimmune response. There is increasing evidence that Th17 cells are involved in the pathological process of autoimmune inflammation and play an important role in the development of experimental autoimmune encephalomyelitis and multiple sclerosis. Its specific mechanism of mediating multiple sclerosis remains unclear, which may be related to the destruction of the blood-brain barrier, the induction of monocyte expansion and differentiation into myeloid dendritic cells, and the promotion of the formation of an inflammatory cytokine network. This review summarizes the role of Th17 cells in the discovery, differentiation and pathogenesis of multiple sclerosis.