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目的：了解咪唑安定对体感诱发电位的影响。方法：选择３０例ＡＳＡＩ～Ⅱ级的脑外科手术病人，根据国际１０～２０系统，在Ｃ３或Ｃ４、ＦＰｚ（参考）和ＳＣ（第二颈椎棘突处）安放盘状记录电极，记录体感诱发电位。均分为三组按剂量（０．２ｍｇ／ｋｇ、０．３ｍｇ／ｋｇ和０．４ｍｇ／ｋｇ）静脉注射咪唑安定，连续观察皮层Ｎ２０、Ｐ２３和颈髓Ｎ１４电位的变化。结果：（１）用药后，皮层Ｎ２０和颈髓Ｎ１４电位的波幅降低，分别抑制到术前的６３．７５％和４８．７５％（Ｐ＜０．０５），苏醒后恢复到基础水平；（２）颈髓Ｎ１４、皮层Ｎ２０和Ｐ２３的潜伏期及中枢传导时间均无显著延长，（３）各剂量组间的ＳＥＰ变化无明显差别。结论：咪唑安定对ＳＥＰ一定程度的抑制作用临床意义不足，可用作ＳＥＰ监测时的静脉麻醉药。
Objective: To understand the effect of midazolam on somatosensory evoked potentials. Methods: Thirty patients with ASAI-Ⅱ brain surgery were selected. According to the international system of 10 to 20, disk-shaped recording electrodes were placed at C3 or C4, FPz (reference) and SC (second cervical spinous process) Somatosensory evoked potential. The rats were divided into three groups and were given midazolam (0.2mg / kg, 0.3mg / kg and 0.4mg / kg) intravenously to observe the change of N20, P23 and N14 potential in the cortex. Results: (1) After treatment, the amplitude of N20 and N14 in the cortex decreased, reaching 63.75% and 48.75% respectively (P <0.05), and recovered to the basal level after waking; 2) There was no significant prolongation of latency and central conduction time in cervical spinal cord N14, cortex N20 and P23, and (3) there was no significant difference in SEP between each dose group. CONCLUSION: Midazolam has a limited clinical significance for the inhibition of SEP and can be used as a venous anesthetic for SEP monitoring.