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目的： 探讨脑室内血肿对丘脑背侧神经元是否具有毒性损伤作用。方法： 在鼠脑室内注血后６ 小时， 观察丘脑背侧神经元的病理组织学改变， 检测丘脑背侧组织ＡＴＰ酶活性及Ｎａ＋ 、Ｋ＋ 、Ｃａ２＋ 含量。结果： 脑室内注血后６ 小时， 丘脑背侧神经元虽未见明显坏死， 但胞内结构已开始发生变化， Ｎａ＋ － Ｋ＋ － ＡＴＰ酶、Ｃａ２＋ － ＡＴＰ酶活性明显降低， Ｎａ＋ 、Ｃａ２＋ 含量则明显增高。结论： 脑室内血肿对丘脑背侧神经元具有毒性损伤作用。
Objective: To investigate whether intracerebral hematoma has a toxic effect on dorsal thalamic neurons. Methods: The histopathological changes of dorsal thalamic neurons were observed 6 hours after intracerebroventricular injection of blood in rats. The activities of ATPase and Na +, K + and Ca2 + in the dorsal thalamus were measured. Results: The dorsal thalamic neurons did not show obvious necrosis at 6 hours after intracerebroventricular injection of blood, but the intracellular structure began to change. The activities of Na + - K + - ATPase and Ca2 + - ATPase were significantly decreased. The contents of Na + and Ca2 + Significantly higher. Conclusion: Intraventricular hematoma has a toxic effect on dorsal thalamic neurons.