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目的：讨论萘对人体的慢性毒效应和亚临床客观检测指标。方法：对河南省萘暴露工人（环境接触萘浓度平均为８．２５～２６．４３ｍｇ／ｍ３）进行了健康监护和医学动态观察。结果：发现长期萘暴露工人的白细胞、血小板减少及眼晶体混浊检出率显著高于对照组（Ｐ＜０．００１）；血清ＳＯＤ同功酶、ＧＳＨ－ＰＸ活性显著低于对照组，而ＬＰＯ水平、神经元特异性烯醇化酶（ＮＳＥ）活性水平以及外周血染色体畸变和微核阳性检出率均显著高于对照组（Ｐ＜０．００１）。神经行为功能检查结果，主要为消极情绪增加，记忆力下降等。事件相关电位Ｐ３００峰潜伏期比对照组显著延长，与对照组差异显著（Ｐ＜０．０５）。结论：慢性低浓度萘暴露对工人主要损害部位（靶器官）有皮肤，眼、血液和神经组织等。ＮＣＴＢ、ＮＳＥ、Ｐ３００三项可作为早期神经受损的客观指标。
Objective: To discuss the chronic toxic effect of naphthalene on human body and the sub-clinical objective detection indexes. Methods: Health monitoring and medical observation were conducted on workers exposed to naphthalene in Henan Province (average concentration of naphthalene in environment was 8.25 ~ 26.43mg / m3). Results: The detection rate of white blood cells, thrombocytopenia and ocular opacity in workers exposed to long-term naphthalene were significantly higher than those in the control group (P <0.001). The activity of SOD isozyme and GSH-PX in serum were significantly lower than those in the control group Level, neuron-specific enolase (NSE) activity levels and peripheral chromosomal aberrations and micronuclei positive rates were significantly higher than the control group (P <0.001). Neurobehavioral function test results, mainly for increased negative emotions, memory loss and so on. Event-related potential P300 peak latency was significantly longer than the control group, significantly different from the control group (P <0.05). CONCLUSION: Chronic low-concentration naphthalene exposures skin, eyes, blood and nerve tissue to the main damage sites (target organs) of workers. NCTB, NSE, P300 three can be used as an objective indicator of early nerve damage.