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目的评价β-内酰胺类抗生素联合大环内酯类与单用氟喹诺酮类治疗社区获得性肺炎的疗效。方法收集符合纳入及排除标准的2010年1月1日至2011年6月30日期间就诊于浙江大学医学院附属第一医院的社区获得性肺炎临床资料并进行分析。结果有89例病例纳入本次研究,其中56例接受β-内酰胺类抗生素加大环内酯类,33例单用氟喹诺酮类治疗。两组患者在年龄,性别组成,合并症,入院前抗生素治疗,影响体温药物的应用,体征及部分实验室检查等方面差异均无统计学意义(P>0.05)。在临床疗效评价上,两组在入院后退热时间、住院时长及CRP下降80%时间差异均无统计学意义(P>0.05),根据PSI进行亚组分析差异亦无统计学意义。结论β-内酰胺类抗生素联合大环内酯类与单用氟喹诺酮类在治疗轻中度社区获得性肺炎时,二者疗效相当。
Objective To evaluate the efficacy of β-lactam antibiotics in combination with macrolides and fluoroquinolones in the treatment of community-acquired pneumonia. Methods The clinical data of community-acquired pneumonia who were admitted to the First Affiliated Hospital of Zhejiang University School of Medicine between January 1, 2010 and June 30, 2011, which met the inclusion and exclusion criteria, were collected and analyzed. Results A total of 89 cases were included in this study. Among them, 56 cases received β-lactam antibiotics and 39 cases fluoroquinolones alone. There was no significant difference between the two groups in terms of age, sex composition, comorbidities, antibiotic treatment before admission, the application of body temperature drugs, signs and some laboratory tests (P> 0.05). There was no significant difference in the clinical efficacy between the two groups in terms of antipyretic time, length of hospital stay and 80% reduction in CRP after admission (P> 0.05). There was no statistically significant difference in subgroup analysis based on PSI. Conclusion β-lactam antibiotics combined with macrolides and fluoroquinolones alone in the treatment of mild to moderate community-acquired pneumonia, both curative effect.