论文部分内容阅读
环腺苷酸(cAMP)为中介细胞对各种激素和神经递质的效应的第二信使。它调节各种代谢过程,包括心肌和平滑肌的收缩、糖原分解、血小板聚集、分泌作用与脂肪分解作用。环鸟苷酸(cGMP)的效应与cAMP相对抗。磷酸二酯酶(PDE)抑制剂抑制PDE水解cAMP,再现cAMP的效应。近年来研究了细胞中三类不同分子形式的PDE,它们的底物特异性不同(cAMP或cGMP),在细胞中的定位(可溶性或与膜结合)不同,对调钙蛋白的反应也不同。不同分子形式的PDE
Cyclic adenosine monophosphate (cAMP) is the second messenger of the effect of mediators on various hormones and neurotransmitters. It regulates a variety of metabolic processes, including cardiac and smooth muscle contraction, glycogen breakdown, platelet aggregation, secretion and lipolysis. The effect of cyclic guanylate (cGMP) is antagonistic to cAMP. Phosphodiesterase (PDE) inhibitors inhibit the hydrolysis of cAMP by PDE and reproduce the effects of cAMP. In recent years, three different molecular forms of PDE have been studied in cells. Their substrate specificity is different (cAMP or cGMP) and their localization in the cell (soluble or membrane-bound) is different from that of calmodulin. Different molecular forms of PDE