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目的探讨急性百草枯中毒患者百草枯血药浓度与患者肺泡灌洗液中内皮素-1(ET-1)的关系。方法百草枯中毒患者15人(观察组),按照患者入院时血药浓度又分为0～4 mg.L-1组、4～8 mg.L-1组、8～12 mg.L-1组、>12 mg.L-1组,对照组为健康体检者10人,采用酶联免疫吸附法测所有研究对象肺泡灌洗液中ET-1的浓度。结果观察组ET-1浓度(31.40±8.12)μg.L-1高于对照组(18.71±6.89)μg.L-1(P<0.05);ET-1的浓度随中毒剂量的升高而升高(P<0.05)。结论百草枯中毒患者肺泡灌洗液中ET-1水平可判断患者病情的重要指标之一。
Objective To investigate the relationship between paraquat concentration and endothelin-1 (ET-1) in patients with acute paraquat poisoning. Methods Fifteen paraquat poisoned patients (observation group) were divided into 0 ~ 4 mg.L-1 group, 4 ~ 8 mg.L-1 group and 8 ~ 12 mg.L-1 according to the plasma concentration Group,> 12 mg.L-1 group, the control group was 10 healthy subjects, and the concentrations of ET-1 in bronchoalveolar lavage fluid of all the study subjects were measured by enzyme-linked immunosorbent assay. Results The concentration of ET-1 in the observation group was significantly higher than that in the control group (31.40 ± 8.12) μg.L-1 (18.71 ± 6.89) μg.L-1 (P <0.05) High (P <0.05). Conclusion The level of ET-1 in bronchoalveolar lavage fluid of patients with paraquat poisoning can be one of the important indexes to judge the condition of patients.