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目的 研究乳腺癌组织中P gp、nm23和p53的变化规律及与乳腺癌复发的关系。方法 应用免疫组化方法检测10例乳腺纤维腺瘤(纤维腺瘤组)和47例乳腺癌病变组织中P gp、nm23和p53 的表达,47例乳腺癌中18例随访3~5年无复发(无复发组),29例3年内复发(复发组),并比较其表达阳性率和表达强度的差异。结果 乳腺癌复发组nm23表达阳性率较纤维腺瘤组低(P<0.05),其阳性表达强度较无复发组低。复发组和无复发组p53表达阳性率均较纤维腺瘤组高(P<0.05),复发组p53阳性表达强度高于无复发组(P<0.05)。复发组和无复发组P gp表达阳性率与纤维腺瘤组比较差异无显著性意义,但其阳性表达强度较纤维腺瘤组低(P<0.01,P<0.025)。结论 p53过表达和nm23低表达对预测乳腺癌复发具有一定价值。
Objective To study the changes of P gp, nm23 and p53 in breast cancer and its relationship with the recurrence of breast cancer. Methods Immunohistochemistry was used to detect the expression of Pgp, nm23 and p53 in 10 cases of fibroadenoma of the breast (fibroadenoma group) and 47 cases of breast cancer, 18 cases of 47 cases of breast cancer were followed up for 3 to 5 years without recurrence (No recurrence group), 29 cases relapsed within 3 years (recurrence group), and compared the difference between the positive expression rate and the expression intensity. Results The positive expression rate of nm23 in breast cancer recurrence group was lower than that in fibroadenoma group (P <0.05), and the positive expression intensity of nm23 was lower than that in non-recurrence group. The positive rates of p53 in recurrence group and non-recurrence group were higher than those in fibroadenoma group (P <0.05). The positive expression of p53 protein in recurrence group was higher than that in non-recurrence group (P <0.05). The positive expression rate of P gp in recurrence group and no recurrence group was not significantly different from that in fibroadenoma group, but the positive expression intensity was lower than that in fibroadenoma group (P <0.01, P <0.025). Conclusion The overexpression of p53 and the low expression of nm23 have some value in predicting the recurrence of breast cancer.