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目的研究nm23和ER在乳腺癌组织中的表达及与转移的关系。方法采用免疫组化法(S-P法),对2000~2005年我科诊断的78乳腺癌患者的病理切片做回顾性分析。结果nm23、ER在无淋巴结转移的乳腺癌组阳性表达分别为84.4%、78.1%,明显高于有淋巴结转移的乳腺癌组(P<0.01)。组织学分级中,分化程度越高,nm23、ER的阳性率越高(P<0.01和P<0.05)。结论乳腺癌的nm23和ER阳性表达率无淋巴结转移组明显高于有淋巴结转移组。nm23、ER阳性的乳腺癌分化较高,淋巴结转移发生较晚,预后较好。nm23和ER可作为判断乳腺癌预后的指标。
Objective To study the expression of nm23 and ER in breast cancer and its relationship with metastasis. Methods The immunohistochemical method (S-P method) was used to retrospectively analyze the pathological sections of 78 breast cancer patients diagnosed in our department from 2000 to 2005. Results The positive expression rates of nm23 and ER in breast cancer without lymph node metastasis were 84.4% and 78.1%, respectively, which were significantly higher than those in patients with lymph node metastasis (P <0.01). Histological grade, the higher the degree of differentiation, nm23, the higher the positive rate of ER (P <0.01 and P <0.05). Conclusion The positive rates of nm23 and ER in breast cancer without lymph node metastasis were significantly higher than those with lymph node metastasis. nm23, ER-positive breast cancer higher differentiation, lymph node metastasis later, the prognosis is good. nm23 and ER can be used as indicators to determine the prognosis of breast cancer.