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目的以壳聚糖和海藻酸钠为基质材料,在此基础上加入纳米CdS(硫化镉)制备缓释性能优异的载药微球。该实验包裹的药物为卵磷脂,卵磷脂在发挥功效的同时兼作两性离子型表面活性剂,可望替代当前较多采用的非离子型表面活性剂司盘-80或吐温-80。方法以微球的包封率为制备工艺优化指标,利用复凝聚法,通过正交实验筛选微球的最佳制备工艺条件,同时在最佳工艺基础上加入CdS制备微球。结果最佳制备工艺:壳聚糖0.24 mg/ml,搅拌速度800 r/min,反应温度25℃,交联剂戊二醛用量2.0 ml,CdCl20.004 mol,Na2S 0.004 mol。结论用液体石蜡、卵磷脂、壳聚糖、海藻酸钠、戊二醛,不添加非离子型表面活性剂司盘-80或吐温-80,即可制备形态规整的微球;加入CdS纳米粒子的微球具有较好的缓释作用。
Aim To use chitosan and sodium alginate as matrix materials, nano-CdS (cadmium sulfide) was added to prepare sustained-release microspheres. The experimental package of drugs for the lecithin, lecithin play both zwitterionic surfactants, is expected to replace the more commonly used non-ionic surfactant Span -80 or Tween -80. Methods The entrapment efficiency of microspheres was used as the optimization index of preparation process. The optimal preparation conditions of microspheres were screened by orthogonal test by complex coacervation method. At the same time, microspheres were prepared by adding CdS based on the best technology. Results The optimum preparation conditions were as follows: chitosan 0.24 mg / ml, stirring speed 800 r / min, reaction temperature 25 ℃, amount of glutaraldehyde crosslinking agent 2.0 ml, CdCl20.004 mol, Na2S 0.004 mol. Conclusions The structured microspheres can be prepared with liquid paraffin, lecithin, chitosan, sodium alginate and glutaraldehyde without addition of non-ionic surfactant Span-80 or Tween-80. CdS nanoparticles Particle microspheres have a better sustained release effect.