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本协作组采用ABC免疫组化法检测了118例肝炎、肝硬化、肝癌患者骨髓细胞,有56例(47.5％)HBV抗原阳性,其中慢乙肝阳性率为44.4％(24/54),肝硬化阳性率39.1％(18/46),肝癌阳性率77.8％(14/18)。从而可证HBV可以感染肝病人的骨髓细胞。为查清骨髓细胞对HBV的易感程度及骨髓细胞中哪类细胞易受感染.我们对肝炎、肝硬化、肝癌各组前10例病人检查了骨髓细胞各100个(各病程各1000个细胞),慢乙肝受感染细胞为197/1000(19.7％),肝硬化为210/1000(21％),肝癌为206/1000(20.6％),平均为613/3000(20.4％),各组P>0.05。查骨髓细胞分类观察,感染HBV者均为粒细胞、晚幼细胞以后细胞,其中晚幼为281/3000(9.4％),杆状细胞为187/3000(6.2％),分叶核为145/3000(4.8％)。
The cooperative group detected the bone marrow cells of 118 patients with hepatitis, cirrhosis and hepatocellular carcinoma by ABC immunohistochemistry, 56 cases (47.5%) were positive for HBV antigen, the positive rate of chronic hepatitis B was 44.4% (24/54), cirrhosis The positive rate was 39.1% (18/46) and the positive rate of liver cancer was 77.8% (14/18). Thus permit HBV can infect patients with bone marrow cells of liver. In order to find out the susceptibility of bone marrow cells to HBV and which cells in bone marrow cells are susceptible to infection, we examined 100 bone marrow cells in each of the first 10 patients in each group of hepatitis, cirrhosis and liver cancer (1000 cells in each course ), 197/1000 (19.7%) for chronic hepatitis B, 210/1000 (21%) for cirrhosis and 206/1000 (20.6%) for hepatocellular carcinoma with an average of 613/3000 (20.4% > 0.05. Check the classification of bone marrow cells were observed, those infected with HBV were granulocytes, late cells after the cells, of which late young 281/3000 (9.4%), rod-shaped cells 187/3000 (6.2%), leaf lobes 145 / 3000 (4.8%).