论文部分内容阅读
目的:探讨276例多囊卵巢综合征(PCOS)患者的相关临床特征。方法:将276例PCOS患者的一般特征、生殖激素水平和卵巢生理情况与健康女性进行对比分析。结果:276例PCOS患者中,270例患者(97.83%)双侧卵巢增大,伴有多个囊性卵泡;246例患者(89.13%)出现月经紊乱症状;124例患者(44.93%)出现胰岛素抵抗;82例患者(29.71%)BMI>25;78例患者(28.26%)出现高雄激素血症;64例患者(23.19%)出现多毛症。PCOS患者的睾酮(T)、黄体生成素(LH)、催乳素(PRL)、雌二醇(E2)水平升高,且高于健康女性,差异有统计学意义(P<0.05);子宫内膜厚度、卵泡数目、卵巢容积、卵巢髓质容积低于健康女性,差异有统计学意义(P<0.05);卵巢基质血流阻力指数(RI)和搏动指数(PI)低于健康女性,差异有统计学意义(P<0.05),空腹血糖和空腹胰岛素水平高于健康女性,差异有统计学意义(P<0.05)。结论:中国PCOS患者以卵巢改变为主,生殖激素改变明显,该类患者中一半左右伴有胰岛素抵抗,少数患者伴有体重增加、高雄激素血症、多毛症,与欧美国家患者症状有差异。
Objective: To investigate the clinical features of 276 patients with polycystic ovary syndrome (PCOS). Methods: The general characteristics of 276 PCOS patients, reproductive hormone levels and ovarian physiology were compared with healthy women. RESULTS: Of the 276 PCOS patients, 270 (97.83%) had bilateral ovarian enlargement with multiple cystic follicles; 246 (89.13%) had menstrual disorders; 124 (44.93%) had insulin Resistance; 82 patients (29.71%) had BMI> 25; 78 patients (28.26%) had hyperandrogenism; 64 patients (23.19%) had hirsutism. The levels of testosterone, LH, PRL and E2 in PCOS patients were significantly higher than those in healthy women (P <0.05); The RI and PI of ovarian stroma were lower than those of healthy women, the difference was statistically significant There was statistical significance (P <0.05), fasting blood glucose and fasting insulin levels were higher than healthy women, the difference was statistically significant (P <0.05). CONCLUSIONS: The majority of PCOS patients in China are ovarian changes with obvious changes of reproductive hormones. About half of these patients are accompanied by insulin resistance. A few patients are associated with weight gain, hyperandrogenism, hirsutism, and symptoms in European and American patients.