【摘 要】
：
Autism spectrum disorder can be differentiated into three subtypes (aloof,passive,and active-but-odd)based on social behaviors according to the Wing Subgroups Questionnaire (WSQ).However,the correlations between the scores on some individual items and the
【机 构】
：
Neuroscience Research Institute, Peking University, Beijing 100083, China;Key Laboratory for Neurosc
论文部分内容阅读
Autism spectrum disorder can be differentiated into three subtypes (aloof,passive,and active-but-odd)based on social behaviors according to the Wing Subgroups Questionnaire (WSQ).However,the correlations between the scores on some individual items and the total score are poor.In the present study,we translated the WSQ into Chinese,modified it,validated it in autistic and typicallydeveloping Chinese children,and renamed it the Beijing Autism Subtyping Questionnaire (BASQ).Our results demonstrated that the BASQ had improved validity and reliability,and differentiated autistic children into these three subtypes more precisely.We noted that the autistic symptoms tended to be severe in the aloof,moderate in the passive,and mild in the active-but-odd subtypes.The modified questionnaire may facilitate etiological studies and the selection of therapeutic regimes.
其他文献
Mental disorder is defined as a syndrome characterized by clinically significant disturbance in an individual\'s cognition,emotion,or behavior that reflects a dysfunction in the psychological,biological,or developmental processes underlying mental funct
Investigating the pathophysiological mechanisms underlying brain disorders is a priority if novel therapeutic strategies are to be developed.In vivo studies of animal models and in vitro studies of cell lines/primary cell cultures may provide useful tools
Previous genetic fate-mapping studies have indicated that embryonic glial fibrillary acidic proteinpositive (GFAP+) cells are multifunctional progenitor/neural stem cells that can produce astrocytes as well as neurons and oligodendrocytes throughout the a
Cyproheptadine (CPH),a first-generation antihistamine,enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway.In this study,we aimed to determine the effects of CPH on n
Neuroplastin 65 (Np65) is an immunoglobulin superfamily cell adhesion molecule involved in synaptic formation and plasticity.Our recent study showed that Np65-knockout (KO) mice exhibit abnormal cognition and emotional disorders.However,the underlying mec
Prognostication of coma patients after brain injury is important,yet challenging.In this study,we evaluated the predictive value of amplitude-integrated electroencephalography (aEEG) for neurological outcomes in coma patients.From January 2013 to January
Severe brain injury can lead to acute or chronic disorders of consciousness (DOC),and the latter represents a more critical challenge in diagnosis and management.For most chronic unconsciousness survivors with preserved sleepwake cycles,including vegetati
The vegetative state is a complex condition with unclear mechanisms and limited diagnostic,prognostic,and therapeutic methods.In this study,we aimed to explore the proteomic profile of tears from patients in a traumatic vegetative state and identify poten
Recently,two researches by Doucet et al.and Collin et al.used functional neuroimaging as a tool to improve the management of schizophrenia and other psychotic disorders [1,2].We would like to highlight several issues in relation to cardiopulmonary comorbi
Huntington\'s disease (HD) is a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin (Htt) protein.Mutant Htt causes synaptic transmission dysfunctions by interfering in the expression of synaptic proteins,leading to early HD