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近年来对维生素K(VK)药理作用的研究和临床应用证明,VK具有多方面的生理和药理作用,本文仅就VK对平滑肌的作用及应用做一综述. 一、实验研究 1974年黄天俊等首先报道维生素K_3(VK_3)(2.4×10~(-5)M)对兔离体肠肌自动收缩及乙酰胆碱引起的肠肌收缩有明显的抑制作用.尔后曾慧玲等又报道VK_2(1.3×10~(-4)M)
In recent years, pharmacological effects of vitamin K (VK) research and clinical applications have proved that VK has a wide range of physiological and pharmacological effects, this article only on the role of VK on smooth muscle and its application to do a review.First, the experimental study of Huang Tianjun 1974 first Reported vitamin K_3 (2.4 × 10 ~ (-5) M) on isolated rabbit intestinal muscle contraction and acetylcholine contraction caused by a significant inhibitory effect.After Zeng Huiling et al reported VK_2 (1.3 × 10 ~ (-4) M)