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目的了解宁波市细菌性痢疾流行特征,为防控工作提供依据。方法采用SPSS 17.0和Excel2003软件,对宁波市2004-2014年细菌性痢疾疫情资料进行数据统计处理,采用Pearsonχ~2检验,P<0.05为差异有统计学意义,分离和收集志贺菌进行鉴定分型、耐药性和致病力检测。结果宁波市细菌性痢疾年发病率在1.78/10万~42.59/10万,平均为18.69/10万。全年均可发病,发病高峰为8~9月。志贺菌流行株以B群志贺菌为主,D群志贺菌为次,呈福氏2a血清型、福氏c亚型和宋内氏志贺菌格局。菌株耐药严重,多为多重耐药株;携带毒力基因种类多、毒性强。结论宁波市细菌性痢疾发病率逐年下降,已维持在较低水平,但菌株的血清型在转换,耐药性和毒力显示其有较强的致病性,引起暴发与流行的因素仍未改变,提示应加强细菌性痢疾的监测与防控。
Objective To understand the epidemic characteristics of bacillary dysentery in Ningbo and to provide basis for prevention and control. Methods SPSS 17.0 and Excel2003 software were used to analyze the data of epidemic situation of bacillary dysentery from 2004 to 2014 in Ningbo. The Pearsonχ ~ 2 test was used to test the data. The difference was statistically significant at P <0.05. The isolates of Shigella were collected and identified Type, drug resistance and pathogenicity testing. Results The annual incidence of bacterial dysentery in Ningbo was between 1.78 / 100000 and 42.59 / 100000 with an average of 18.69 / 100000. The disease can occur throughout the year, the peak incidence of 8 to 9 months. Strain Shigella strains mainly Shigella group B, Shigella group D secondary times, was the type 2a serotype Fu, F, subtype and Shigella sonnei pattern. The strains were highly drug-resistant, mostly multi-resistant strains; more virulence genes and more virulence. Conclusions The incidence of bacillary dysentery in Ningbo is declining year by year and has been kept at a low level. However, the serotypes of the strains show strong pathogenicity due to the transformation, drug resistance and virulence, and the factors causing outbreak and epidemic have not yet reached Changes, tips should be strengthened bacterial dysentery monitoring and prevention and control.