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将金黄色葡萄球菌与赖氨酸月桂基酯混合后注入三组小鼠的皮下,赖酯剂量分别为186mg/kg、420mg/kg 及950mg/kg。通过观察组织切片中炎症反应程度来研究其抗菌活性。结果为:①赖酯剂量为186mg/kg 时,脓肿阳性率、脓肿大小及中性粒细胞浸润程度均低于菌感染对照组,而与青霉素治疗组相似。提示该剂量赖酯在体内有一定抗菌活性。420mg/kg 及950mg/kg 组的脓肿阳性率、脓肿大小及中性粒细胞浸润程度与菌感染对照组相似,而与青霉素治疗组的有差异。提示赖酯剂量增到420～950mg/kg时,在体内无抗菌活性。②赖酯可造成正常组织坏死,坏死率随剂量加大而增高(分别为23%,46%和61%)。③三种治疗剂量的赖酯均无明显促进肉芽组织生长的作用。
Staphylococcus aureus and lauryl lysine were mixed and injected into the subcutaneous tissues of three groups of mice. The dose of lysester was 186 mg/kg, 420 mg/kg, and 950 mg/kg, respectively. The antibacterial activity was studied by observing the degree of inflammation in tissue sections. The results were as follows: When the dose of rasal ester was 186 mg/kg, the abscess positive rate, abscess size, and neutrophil infiltration were all lower than those in the bacterial infection control group, but similar to the penicillin treatment group. It is suggested that the dose of lysate has certain antibacterial activity in vivo. The abscess positive rate, abscess size, and neutrophil infiltration in the 420 mg/kg and 950 mg/kg groups were similar to those in the bacterial infection control group, but were different from those in the penicillin treatment group. It is suggested that when the dosage of lysester is increased to 420-950 mg/kg, there is no antibacterial activity in vivo. 2 Lysine can cause normal tissue necrosis, and the necrosis rate increases with increasing dose (23%, 46%, and 61%, respectively). 3 The three therapeutic doses of lysate did not significantly promote the growth of granulation tissue.