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HBV引起的肝细胞癌居我国恶性肿瘤所致死亡原因的第一位。本文从HBV基因组流行病学入手，系统研究了HBV致癌各阶段病毒进化规律及其与宿主遗传因素的交互作用，综合分析了载脂蛋白B mRNA编辑酶催化多肽家族在炎-癌转化中的桥梁作用，进而提出了普适性“癌症进化发育学”理论体系。癌症进化发育学为理解炎症促进癌症发展的机制奠定了理论基础，对多种恶性疾病的特异性预防、预测、早期诊断和靶向治疗具有重要意义。“,”Hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV) is the first cause of cancer-caused death in China. This study, from the perspective of HBV genomic epidemiology, systematically investigated the evolution of HBV and their interaction with host genetic factors in each stage of HBV carcinogenesis and comprehensively analyzed the role of apolipoprotein B mRNA editing enzyme catalytic polypeptides (APOBEC) family in the inflammation-to-cancer transformation. Based on our findings and related studies, we proposed “cancer evolution and development” (Cancer n Evo-Dev) theoretical system suitable for most cancer types. Cancer n Evo-Dev lays a theoretical foundation for understanding the mechanism of inflammation to promote the development of cancer, which is of great significance for the specific prevention, prediction, early diagnosis, and targeted therapy of malignant diseases.n