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我们在研究用人肝细胞膜特异性脂蛋白与弗氏完全佐剂免疫豚鼠引起的免疫性肝炎模型时,发现肝细胞及小胆管上皮细胞都可以产生胶原纤维。肝脏的病变表现为门管区周围的狄氏腔扩张,充满均匀红染物质,小胆管壁增厚,其外层亦染成均匀红色,与狄氏腔内物质相似。电镜下扩张的狄氏腔内及小胆管壁的周围均有大量微纤维沉积,微纤维(前胶原)是由肝细胞及小胆管上皮细胞合成通过分泌泡排至细胞外的,也有许多微纤
When we studied the immunological hepatitis model induced by guinea pigs with human hepatocyte membrane-specific lipoprotein and Freund’s complete adjuvant, we found that both hepatocytes and small bile duct epithelial cells could produce collagen fibers. Liver lesions showed Debye cavity around the portal area expansion, filled with uniform red dye material, small bile duct wall thickening, the outer layer is also stained red, similar to the substance within the Di’s cavity. Under the electron microscope, there are a large number of microfibrillar deposits around the dilator lumen and the small bile duct wall. Microfibrillar (procollagen) is synthesized by the hepatocytes and small bile duct epithelial cells and secretes into the extracellular space through excretory vesicles, and many microfibrils