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本文报道了普通感冒和无热性上呼吸道感染对标准的麻疹-流行性腮腺炎-风疹(MMR)疫苗免疫效果的干扰现象。受试对象为来到诊所作常规体检和免疫接种的15～18月龄儿童。以家长诉说患感冒并经体检发现有上呼吸道感染体征者作为感冒组,以无任何上呼吸道感染症状且在接种前1个月内无感冒史者作为健康对照组。发热(≥38℃)、恶性肿瘤或其他免疫缺陷疾病,对MMR疫苗过敏或在3个月内注射过免疫球蛋白者均不作为观察对象。分别收集免疫前和免疫后6～8周的血清样本,采用间接荧光法检测麻疹抗体。
This article reports the interference of the common cold and non-infectious upper respiratory tract infections against the immunization of standard measles-mumps-rubella (MMR) vaccines. Subjects came to the clinic for routine physical examination and immunization of 15 to 18-month-old children. To parents complained of influenza and physical examination found signs of upper respiratory tract infection as a cold group, without any symptoms of upper respiratory tract infection within 1 month before vaccination and no history of a cold as a healthy control group. Fever (> 38 ° C), malignancy or other immunodeficiency disease, allergy to MMR vaccine, or immunoglobulin injections within 3 months were excluded. Serum samples were collected before immunization and 6-8 weeks after immunization, respectively, and indirect immunofluorescence assay was used to detect measles antibody.