论文部分内容阅读
目的:随着表皮生长因子受体(epidermal growth factor receptor,EGFR)靶点治疗药物在其它肿瘤治疗中的应用,能否在妇科肿瘤中应用并取得疗效,已经得到学者们的重视。但在临床应用之前,必须明确EGFR与妇科肿瘤发生发展的关系及其机制。因此,我们来探讨表皮生长因子受体EGFR信号通路在维吾尔族不同级别宫颈病变组织中的差异表达及其临床意义。方法:应用免疫组织化学方法检测EGFR、P-EGFR、ERK 1/2、P-ERK1/2在108例子宫颈癌,47例CIN,79例正常宫颈组织中的表达,并分析其与临床病理参数的关系。结果:EGFR在子宫颈癌、CIN及正常宫颈组织中的阳性表达率分别是74.10%、66%、27.80%(P<0.01);P-EGFR在三组间的阳性表达率分别是55.60%、74.50%、20.30%(P<0.01);ERK1/2在三组间的阳性表达率分别是60.10%、76.60%、25.30%(P<0.01);P-ERK1/2在三组间的阳性表达率分别是44.40%、66%、24.10%(P<0.01),其在宫颈癌中EGFR与与浸润深度、淋巴结转移有关;ERK与肿瘤的临床分期、远处转移有关,而且在宫颈癌中EGFR与P-EGFR、ERK 1/2、P-ERK1/2的表达成正相关(P<0.05)。结论:EGFR、P-EGFR、ERK1/2、P-ERK1/2的表达与宫颈癌的发生、发展相关,促进宫颈癌的浸润和转移,抑制EGFR信号通路可能为多靶点联合治疗宫颈癌提供新的方向。
OBJECTIVE: With the application of epidermal growth factor receptor (EGFR) target therapy in the treatment of other tumors, whether it can be applied in gynecological tumors and achieved curative effect has attracted the attention of scholars. However, before clinical application, we must clarify the relationship between EGFR and gynecologic oncogenesis and its mechanism. Therefore, we explore the differential expression of epidermal growth factor receptor EGFR signaling pathway in different levels of cervical lesions in Uighur and its clinical significance. Methods: The expressions of EGFR, P-EGFR, ERK1 / 2 and P-ERK1 / 2 in 108 cases of cervical cancer, 47 cases of CIN and 79 cases of normal cervical tissue were detected by immunohistochemical method and analyzed with clinicopathological parameters Relationship. Results: The positive expression rates of EGFR in cervical cancer, CIN and normal cervical tissues were 74.10%, 66% and 27.80% respectively (P <0.01). The positive rates of P-EGFR in three groups were 55.60% 74.50% and 20.30%, respectively (P <0.01). The positive expression rates of ERK1 / 2 in three groups were 60.10%, 76.60% and 25.30% The rates of EGFR were 44.40%, 66%, 24.10% respectively (P <0.01). The expression of EGFR in cervical cancer was related to the depth of invasion and lymph node metastasis. ERK was related to the clinical stage and distant metastasis of tumor. There was a positive correlation between the expression of P-EGFR, ERK1 / 2 and P-ERK1 / 2 (P <0.05). Conclusion: The expressions of EGFR, P-EGFR, ERK1 / 2 and P-ERK1 / 2 are correlated with the occurrence and development of cervical cancer and promote the infiltration and metastasis of cervical cancer. Inhibition of EGFR signaling pathway may provide multi-target combination therapy for cervical cancer New direction