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作者采用国产ＳＧＹ－３型多功能消化道检测仪对８０例具有胃－食管返流（ＧＥＲ）症状患者进行了食管测压研究。患者分为两组：Ａ组３３例，内镜及活检食管粘膜正常；Ｂ组４７例，内镜及活检均证实有食管炎。正常对照组６０例。食管炎患者给予吗丁啉口服。结果显示：（１）Ａ、Ｂ两组患者食管下括约肌压力（ＬＥＳＰ）、胃－食管屏障压、食管下括约肌（ＬＥＳ）松驰率明显降低，ＬＥＳ松驰时间明显延长、ＬＥＳ长度（ＬＥＳＬ）短于正常，食管蠕动波压力明显降低（Ｐ＜０．０５，０．０１）；（２）Ｂ组ＬＥＳＰ、胃－食管屏障压明显低于Ａ组（Ｐ＜０．０５），这与临床上ＧＥＲ症状发生率Ｂ组高于Ａ组相符合；（３）吗丁啉使Ｂ组ＬＥＳＰ胃－食屏障压分别升高０．３９±０．４８和０．３４±０．４９ｋＰａ，但对食管蠕动无影响。因而，应用吗丁啉治疗ＬＥＳ功能低下引起的ＧＥＲ是合理、有效的。
The authors used a homemade SGY-3-type multi-function gastrointestinal tract analyzer 80 esophageal manometry patients with gastroesophageal reflux disease (GER) symptoms. Patients were divided into two groups: A group of 33 cases, endoscopic and biopsy esophageal mucosa normal; B group 47 cases, endoscopic and biopsy confirmed esophagitis. 60 cases of normal control group. Patients with esophagitis given domperidone orally. The results showed that: (1) The relaxation rate of LESP, gastric-esophageal barrier pressure and lower esophageal sphincter (LES) were significantly decreased in group A and group B, the LES relaxation time was significantly longer, LESL, (2) The LESP and gastric-esophageal barrier pressure in group B were significantly lower than those in group A (P <0.05), which was not related to the clinical The incidence of upper GER in group B was higher than that in group A; (3) For morphine, the gastric-food barrier pressure of LESP increased by 0.39 ± 0.48 and 0.34 ± 0.49 kPa in group B, No effect of esophageal peristalsis. Therefore, the use of domperidone treatment LER ineffective GER is reasonable and effective.