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The relationship between the hepatic ischemia/reperfusion (I/R) injury and the b alance of nitric oxide/endothelins (NO/ET) was studied. The changes of the ratio of NO/ET and the hepatic injury were observed in a rat hepatic I/R model pretre ated with several tool drugs. In the acute phase of hepatic I/R injury, the rati o of plasma NO/ET was reduced from 1.58 ± 0.20 to 0.29 ± 0.05 ( P < 0.01) a nd the hepatic damage deteriorated. NO donor L Arg and ET receptor antagonist T AK 044 cou ld alleviate the hepatic I/R injury to some degree, whereas NO synthase inhibito r L NAME aggravated the damage. It was concluded that the hepatic I/R injury mi ght be related with the disturbance of the NO/ET balance. Regulation of this bal ance might have an effect on the I/R injury.
The relationship between the hepatic ischemia / reperfusion (I / R) injury and the b alance of nitric oxide / endothelins (NO / ET) was studied. The changes of the ratio of NO / ET and the hepatic injury were observed in a rat hepatic In the acute phase of hepatic I / R injury, the rati o of plasma NO / ET was reduced from 1.58 ± 0.20 to 0.29 ± 0.05 (P <0.01) a nd the hepatic damage It has been said that the hepatic I / R injury mi ght be related with the disturbance of the NO / ET balance. Regulation of this bal ance might have an effect on the I / R injury.