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利用Mydlarz和Jones模型(MJ2),对乙酸丁酯中青霉素亚砜的成核与生长动力学进行研究。通过矩量法对MJ2模型进行处理后,利用晶体产品的粒度分布计算得到青霉素亚砜的生长速率与成核速率,然后利用最小二乘法拟合回归求解出成核与生长动力学方程参数。通过实验设计考察了过饱和度、温度与搅拌速度对青霉素亚砜晶体成核和生长过程的影响。研究表明青霉素亚砜晶体生长速率随过饱和度比的增加呈现指数型增长,确定青霉素亚砜晶体生长属于晶体表面生长控制过程。由于高速搅拌会增加青霉素亚砜晶体的破碎,促进了二次成核过程,随着搅拌速度的增加,晶体生长速率出现小幅下滑,而成核速率则明显升高。青霉素亚砜成核与生长动力学研究将有助于工业生产过程优化。
The nucleation and growth kinetics of penicillin sulfoxide in butyl acetate were investigated using Mydlarz and Jones models (MJ2). After the MJ2 model was processed by the moment method, the growth rate and the nucleation rate of penicillin sulfoxide were calculated by using the particle size distribution of the crystal product, and then the parameters of nucleation and growth kinetics equations were solved by regression fitting by the least square method. The effects of supersaturation, temperature and stirring speed on the nucleation and growth of penicillin sulfoxide crystals were investigated by experimental design. The results showed that the growth rate of penicillin sulfoxide increased exponentially with the increase of supersaturation ratio. It was confirmed that penicillin sulfoxide crystal growth belonged to the crystal growth control process. As the high-speed agitation increases the fragmentation of penicillin sulfoxide crystals and promotes the secondary nucleation process, the crystal growth rate decreases slightly with the increase of agitation speed, and the nucleation rate increases obviously. Penicillin sulfoxide nucleation and growth kinetics studies will help optimize the industrial production process.