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文献报告由于骨皮质和海绵状骨生化特性的不同,在握入过量氟化物后可产生不同的效应。摄入氟化物还可使发育良好的海绵状骨小梁的网眼,由于硫酸葡聚糖胺的增加而形成软骨。作者报告了骨皮质、海绵状骨及血清中一种重要的糖蛋白成分——唾液酸的情况。用体重为600～800 g家兔,每天饲给10mg/kg的NaF共12个月,分别于3,8,10和12个月时,每组用5只动物,以心脏穿刺法取血液,并分离血清。从股骨取骨皮质,从骨盆带的髂嵴部取海绵状骨,除去骨髓。用1:1的乙醚-丙酮混合液和丙酮制取脱脂骨粉。测定血清和骨中唾液酸含量。对照组不给
The literature reports that due to differences in the biochemical properties of the cortical and cavernous bones, different effects can be produced when excess fluoride is grasped. Fluoride ingestion also allows the well-developed spongy trabecular meshwork to form cartilage due to the increase of dextran sulfate. The authors report the condition of sialic acid, an important glycoprotein in cortical bone, spongy bone and serum. The body weight of 600 ~ 800 g rabbits fed 10mg / kg of NaF every day for 12 months, respectively, at 3, 8, 10 and 12 months, with 5 animals in each group to take the blood of the heart puncture method, And serum is separated. Remove the cortical bone from the femur, take the cavernous bone from the iliac crest of the pelvic band, and remove the bone marrow. Defatted bone meal was made with a 1: 1 mixture of ether and acetone and acetone. Sialic acid levels in serum and bone were measured. The control group did not give