Precise Microdeletion Detection of Prader-Willi Syndrome with Array Comparative Genome Hybridizatio

• 作 者: XIN-Yu SHAO RONG ZHANG CHENG H
• 机 构: DepartmentofEndocrinologyandMetabolism,DepartmentofEndocrinologyandMetabolism
• 出 处: 生物医学与环境科学：英文版
• 发表日期: 2010年3期
• 关键词: 比较基因组杂交 区域检测 综合征 阵列 亚硫酸氢钠 鲜红斑痣 快速筛选 基因组印记 Prader-Willi Syndrome array CGH Bisu
• 基金项目: ACKNOWLEDGEMENTS This work was supported by grants from National 973 Program （2006CB503901）, Shanghai Key Laboratory of Diabetes Mellitus （08DZ2230200） Major Program of Shanghai Municipality for Basic

<正>Objective Prader-Willi Sydrome(PWS) is a human disorder related to genomic imprinting defect on 15q11-13.It is characterized by a series of classic features such as hypotonia,hyperphagia,obesity,osteoporosis,typical facial and body dysmorphosis,h