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目的:探讨龙芽葱木皂苷的抗炎镇痛作用。方法:镇痛实验选用热板法和醋酸扭体法;炎症模型采用角叉菜胶、弗氏完全佐剂、棉球法,以肿胀程度、肉芽肿重为指标。结果:龙芽葱木皂苷具有明显的解热镇痛作用,对急性和慢性炎症均有明显的抑制作用(P<0.05或P<0.01);使佐剂致病变大鼠外周血白细胞介素-6、白细胞介素-8的含量明显降低,白细胞介素- 10水平升高(P<0.05或P<0.01)。结论:龙芽葱木皂苷有较好的镇痛、抗炎效果。
Objective: To explore the anti-inflammatory and analgesic effects of radix saponaria. Methods: The hot plate method and the acetic acid writhing method were used in the analgesic experiment. Carrageenan, Freund’s complete adjuvant and cotton ball method were used in the inflammation model. The degree of swelling and granuloma weight were used as indicators. RESULTS: Longyao saponin had significant antipyretic and analgesic effects, and had significant inhibitory effects on both acute and chronic inflammation (P<0.05 or P<0.01). It also caused peripheral blood interleukin in rats with adjuvant-induced lesions. -6. The content of interleukin-8 was significantly reduced and the level of interleukin-10 was increased (P <0.05 or P <0.01). Conclusion: Dragon bud saponin has better analgesic and anti-inflammatory effects.