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C-N键广泛存在于天然产物和药物中间体中,而利用脱羧-Mannich反应可以有效地构建碳-氮键,是合成β-氨基醇和β-氨基取代的羰基化合物以及β-内酰胺的有效方法之一。本文介绍了不对称催化脱羧-Mannich反应的研究进展。
CN bonds are widely found in natural products and pharmaceutical intermediates, and the decarboxylation-Mannich reaction can effectively construct carbon-nitrogen bonds, which is an effective method for synthesizing β-aminoalcohols and β-amino substituted carbonyl compounds and β-lactams one. This article describes the progress of asymmetric catalytic decarboxylation-Mannich reaction.