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洋地黄的应用非常普遍。由于其治疗剂量与中毒剂量接近,中毒现象并非鲜见。处理方面除及时停药外,无特效解毒药。洋地黄中毒引起的严重心律紊乱对各种治疗反应不好时,可导致死亡。洋地黄和心肌细胞膜上的受体结合产生正性肌力作用。以地高辛免疫羊得到特异性很强的抗血清抗体,后者与地高辛的结合力超过细胞膜受体而形成地高辛与抗体的复合物从肾脏排出,起到解毒作用。但以完整的地高辛抗体作为生理学试剂有以下缺点:(1)在血液中存留时间过长;(2)在慢性实验中产生免疫作
The application of digitalis is very common. Due to its therapeutic dose and poisoning dose close, poisoning is not uncommon. In addition to promptly stop treatment, no special antidote. Severe heart rhythms caused by digitalis poisoning can result in death when they respond poorly to various therapies. Digitalis and myocardial cell membrane receptors produce positive inotropic effect. To digoxin immune sheep to obtain a very specific antiserum antibody, the latter binding with digoxin than the cell membrane receptor and the formation of digoxin and antibody complexes excreted from the kidneys, play a detoxification. However, the use of intact digoxigenin as a physiological reagent has the following disadvantages: (1) long retention time in the blood; (2) immunization in chronic experiments