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[目的]:研究VEGF-C在胃癌中的表达及与淋巴转移的关系。[方法]以我院收治的48例胃癌患者为研究对象,以患者的肿瘤组织石蜡标本为观察组,以癌旁组织石蜡标本为对照组,采用半定量RT-PCR法检测观察组与对照组标本组织VEGF-C的表达。并根据手术病理及影像学检查结果将本组48例胃癌患者分为发生淋巴转移组31例和未发生淋巴转移组17例;分为Ⅰ~Ⅱ期组20例和Ⅲ~Ⅳ期组28例;分为低分化组21例和高中分化组27例;分为术后存活年限≥2年组23例和<2年组25例。对比分析不同组患者标本组织VEGF-C的表达指数。[结果]在VEGF-C的表达指数上,观察组患者高于对照组(P<0.05),发生淋巴转移组患者高于未发生淋巴转移组(P<0.05),Ⅲ~Ⅳ期组患者高于Ⅰ~Ⅱ期组(P<0.05),低分化组患者高于高中分化组(P<0.05),术后存活<2年组患者高于≥2年组(P<0.05)。[结论]发生淋巴转移的胃癌患者VEGF-C表达指数显著升高,且与患者的肿瘤分期、分化程度及术后生存年限密切相关,临床上通过该指标的检测可为胃癌患者病理特征及预后的评估提供参考依据。
[Objective]: To study the expression of VEGF-C in gastric carcinoma and its relationship with lymphatic metastasis. [Methods] Forty-eight patients with gastric cancer treated in our hospital were selected as the research object. The paraffin specimens of the tumor tissues of the patients were taken as the observation group, the paraffin tissues of the para-cancerous tissues were taken as the control group, and the semi-quantitative RT-PCR method was used to observe the observation group and the control group Specimens VEGF-C expression. According to the pathological and imaging findings, 48 patients with gastric cancer were divided into three groups: lymphatic metastasis group (n = 31) and lymphatic metastasis group (n = 17). There were 20 cases in group Ⅰ ~ Ⅱ and 28 cases in group Ⅲ ~ Ⅳ ; Divided into poorly differentiated group of 21 cases and high school differentiation group of 27 cases; divided into survival duration of 2 years after operation in 23 cases and <2 years in 25 cases. The expression of VEGF-C in different groups of patients was analyzed. [Results] The expression of VEGF-C in observation group was higher than that in control group (P <0.05), lymph node metastasis group was higher than that without lymph node metastasis group (P <0.05) In stage Ⅰ ~ Ⅱ group (P <0.05), patients in poorly differentiated group were higher than those in high differentiated group (P <0.05). Patients in postoperative survival <2 years were higher than those in ≥2 years (P <0.05). [Conclusion] The expression of VEGF-C in gastric cancer patients with lymph node metastasis is significantly increased, which is closely related to the tumor stage, differentiation and postoperative survival time. The detection of this index clinically can be used for the pathological features and prognosis of patients with gastric cancer Provide a reference for the assessment.