论文部分内容阅读
Tripterygium wilfordii Hook.f is a medicinal plant having anti-inflammatory and immunosuppressive effects. The therapeutical effect of T. wilfordii on renal diseases is closely related with repairing intrinsic kidney cells. Triptolide (T10) is the major component of monomer found in T. wilfordii, which could protect podocytes by maintaining the activated state of Rho/ROCK pathway, suppressing the expression of p-38MAPK activated by C5b-9 and inhibiting cell apoptosis. In addition, T10 could interfere in presenting antigen of renal tubular epithelial cells and provide the stimulating signal for T cells to block the activation of antigen-specific CD4+ T cells, which is considered to be one of mechanisms for treatment of autoimmune kidney diseases. The protective effect of triptolide on renal intrinsic cells could provide a new direction for further development and utilization of T. wilfordii.
Tripterygium wilfordii Hook.f is a medicinal plant having anti-inflammatory and immunosuppressive effects. Therapeutical effect of T. wilfordii on renal diseases is closely related with repairing intrinsic kidney cells. Triptolide (T10) is the major component of monomer found in T. wilfordii, which could protect podocytes by maintaining the activated state of Rho / ROCK pathway, suppressing the expression of p-38MAPK activated by C5b-9 and inhibiting cell apoptosis. In addition, T10 could interfere in presenting antigen of renal tubular epithelial cells and provide the stimulating signal for T cells to block the activation of antigen-specific CD4 + T cells, which is considered to be one of mechanisms for treatment of autoimmune kidney diseases. The protective effect of triptolide on renal intrinsic cells could provide a new direction for further development and utilization of T. wilfordii.