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目的观察Survivin和P27蛋白在前列腺癌组织中的表达,探讨Survivin和P27与前列腺癌的相关性。方法应用免疫组织化学方法检测48例前列腺癌组织和20例前列腺增生组织Survivin和P27蛋白的表达。结果前列腺癌组织中Survivin和P27蛋白的阳性表达率分别为79.17%(38/48)和47.92%(23/48),前列腺增生组织中Survivin和P27蛋白的阳性表达率分别为0(0/20)和90%(18/20),Survivin和P27蛋白阳性表达率在前列腺癌组织和前列腺增生组织中差异具有统计学意义(P<0.01),Survivin和P27蛋白表达与前列腺癌病理分级、临床分期和骨转移情况具有相关性(P<0.05),前列腺癌Survivin和P27的表达呈负相关(P<0.01)。结论Survivin和P27表达异常在前列腺癌发生发展中具有重要作用,检测Survivin和P27的表达对判断前列腺癌的预后具有重要意义。
Objective To investigate the expression of Survivin and P27 in prostate cancer and to explore the relationship between Survivin and P27 in prostate cancer. Methods Immunohistochemistry was used to detect the expression of Survivin and P27 in 48 cases of prostate cancer and 20 cases of benign prostatic hyperplasia. Results The positive rates of Survivin and P27 protein in prostate cancer tissues were 79.17% (38/48) and 47.92% (23/48), respectively. The positive rates of Survivin and P27 in benign prostatic hyperplasia tissues were 0 (0/20 ) And 90% (18/20) respectively. The positive rates of Survivin and P27 in prostate cancer and benign prostatic hyperplasia tissues were significantly different (P <0.01). Survivin and P27 protein expression were correlated with pathological grade, clinical stage (P <0.05). There was a negative correlation between the expression of Survivin and P27 in prostate cancer (P <0.01). Conclusion The abnormal expression of Survivin and P27 play an important role in the development of prostate cancer. Detecting the expression of Survivin and P27 is of great significance in judging the prognosis of prostate cancer.