论文部分内容阅读
前曾报道使用薄壳型键合填充剂(Permaphase ODS)测定分配系数(log P)得到较满意的结果。使用四种不同洗脱液系统,log P值测定的范围为1.46～5.00。本文选用二种全多孔微粒型键合填充剂进行分配系数测定的研究。实验结果表明这两种填充剂使用一种洗脱液系统(75％甲醇-水),log P值测定的范围为0.76～4.45,大大超过Permaphase ODS使用一种洗脱液测定的log P值的范围,但在此条件下不适用于分配系数的测定。在较小的log P值范围内log P和log k′之间有良好的线性关系,然而同Permaphase ODS的结果相比,测定分配系数的偏差仍较大。
Previously, it was reported that the use of Permaphase ODS to determine the partition coefficient (log P) yielded satisfactory results. Using four different eluent systems, the log P value was measured in the range of 1.46 to 5.00. In this paper, two kinds of fully porous microparticle bonded fillers were selected for the determination of the partition coefficient. The experimental results show that these two fillers use an eluent system (75% methanol-water) with a log P value ranging from 0.76 to 4.45, which greatly exceeds the log P value of a Permaphase ODS assay using an eluent. Range, but it does not apply to the determination of distribution coefficient under this condition. There is a good linear relationship between log P and log k′ in the smaller log P range, but the deviation in the determination of the distribution coefficient is still larger compared to the results of the Permaphase ODS.