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报道了以孕烯醇酮(1)为原料经10步反应,合成了良性前列腺增生症治疗新药非那甾胺,并对关键中间体(4)及(8)的合成进行了条件优化,使其适合工业化生产的要求
Reported that pregnenolone (1) as the raw material through 10 steps reaction, the synthesis of benign prostatic hyperplasia treatment of new drug finasteride, and key intermediates (4) and (8) of the synthesis conditions were optimized so that It is suitable for industrial production requirements