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病历摘要患者女性、24岁,因男性化而入院。患者9岁时患病,其特征为厌食、肝肿大、黄疸和高丙种球蛋白血症。给予可的松后病情改善,但发生明显的柯兴氏综合征样状态。红斑狼疮(LE)细胞试验阴性。肝脏针刺抽吸活检显示慢性肝炎伴肝炎后肝硬化。曾用6-巯基嘌呤治疗数月,但因发生白细胞减少而中断治疗。用强的松治疗后,病情好转,3年后施行急症阑尾切除术,患者能耐受。强的松剂量逐步递减,最后停药。15岁时,患者月经来潮一次。患者17岁时因周围性水肿住院。检查发现甲状腺肿大,肝功能正常。卧床休息几天后水肿消失,出院。患者变得食欲亢进,发生进行性肥胖。19岁时住入本院,检查发现青春期甲状腺机能亢进的征象。总
Patient history Female patient, 24 years old, admitted to hospital for masculinity. Illness at age 9, characterized by anorexia, hepatomegaly, jaundice and hypergammaglobulinemia. The condition was improved after cortisone administration but significant Cushing’s syndrome-like status occurred. Lupus erythematosus (LE) cell test negative. Liver acupuncture aspiration biopsy showed cirrhosis of the liver with chronic hepatitis. Once treated with 6-mercaptopurine for several months, discontinued because of leukopenia. Treatment with prednisone, the condition improved, acute appendectomy after 3 years, the patient can tolerate. Prednisone dose gradually decreased, and finally discontinued. At age 15, the patient has menstrual cramps. The patient was hospitalized with peripheral edema at 17 years of age. Examination found that goiter, normal liver function. Edema disappeared after a few days in bed and discharged. Patients become hyperactive appetite, progressive obesity. 19 years old admitted to our hospital, check the signs of adolescent hyperthyroidism. total